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Results Found: 3

  • The Immune Cell Landscape in Kidneys of Lupus Nephritis Patients
    Internal Dataset

    Authors
    Arnon Arazi
    Deepak A. Rao
    Celine Berthier
    Anne Davidson
    39 more author(s)...
    Description

    Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid...

    Subject
    Kidney
    Lupus Nephritis
    RNA-Seq
    Sequence Analysis, RNA
    Access Rights
    Free to all with registration
    Application Required
    Local Expert
    Anne Davidson
    Arnon Arazi
    Betty Diamond

  • Proteomic and single-cell transcriptomic dissection of human plasmacytoid dendritic cell response to influenza virus
    Internal Dataset

    Authors
    Mustafa Ghanem
    Andrew Shih
    Houman Khalili
    Emily Werth
    4 more author(s)...
    Description

    Plasmacytoid dendritic cells (pDCs) represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons (IFN-I). This function of pDCs is critical for effective antiviral defenses and has been implicated in autoimmunity. While IFN-I and select cytokines have been recognized as pDC secreted products, a comprehensive agnostic profiling of the...

    Subject
    Influenza A Virus, H1N1 Subtype
    Interferon Type I
    Proteomics
    RNA-Seq
    Access Rights
    Free to All
    Local Expert
    Andrew Shih
    Peter Gregersen

  • Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq
    Internal Dataset

    Authors
    Andrew Shih
    Andrew Menzin
    Jill Whyte
    John Lovecchio
    5 more author(s)...
    Description

    Here we investigated different cell populations within ovarian cancer using single-cell RNA seq: fourteen samples from nine patients with differing grades (high grade, low grade and benign) as well as different origin sites (primary and metastatic tumor site, ovarian in origin and fallopian in origin).

    Subject
    Cancer
    Carcinoma, Ovarian Epithelial
    Ovarian Neoplasms
    RNA-Seq
    Sequence Analysis, RNA
    Access Rights
    Free to All
    Local Expert
    Andrew Shih
    Annette Lee
    Peter Gregersen